Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3403975..3404629 Replicon chromosome
Accession NZ_CP057896
Organism Escherichia fergusonii strain RHB10-C23

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVW49_RS16325 Protein ID WP_000244781.1
Coordinates 3403975..3404382 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVW49_RS16330 Protein ID WP_000354046.1
Coordinates 3404363..3404629 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVW49_RS16305 3399932..3401665 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVW49_RS16310 3401671..3402381 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVW49_RS16315 3402406..3403302 - 897 WP_046076901.1 site-specific tyrosine recombinase XerD -
HVW49_RS16320 3403414..3403935 + 522 WP_001055874.1 flavodoxin FldB -
HVW49_RS16325 3403975..3404382 - 408 WP_000244781.1 protein YgfX Toxin
HVW49_RS16330 3404363..3404629 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVW49_RS16335 3404881..3405861 + 981 WP_046076900.1 tRNA-modifying protein YgfZ -
HVW49_RS16340 3405938..3406597 - 660 WP_000250283.1 hemolysin III family protein -
HVW49_RS16345 3406761..3407072 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVW49_RS16350 3407117..3408550 + 1434 WP_181575963.1 6-phospho-beta-glucosidase BglA -
HVW49_RS16355 3408598..3409491 - 894 WP_181576133.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T165753 WP_000244781.1 NZ_CP057896:c3404382-3403975 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T165753 NZ_CP073958:2337353-2337640 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT165753 WP_000354046.1 NZ_CP057896:c3404629-3404363 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165753 NZ_CP073958:2337114-2337353 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References