165738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4561699..4562365 Replicon chromosome
Accession NZ_CP057864
Organism Citrobacter freundii strain RHB12-C19

Toxin (Protein)


Gene name tad Uniprot ID A0A0J1MRN0
Locus tag HVW68_RS21660 Protein ID WP_032938228.1
Coordinates 4562006..4562365 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag HVW68_RS21655 Protein ID WP_181825845.1
Coordinates 4561699..4562016 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVW68_RS21615 4557689..4558501 + 813 WP_061547490.1 shikimate 5-dehydrogenase -
HVW68_RS21620 4558535..4558852 - 318 WP_003841409.1 CcdB family protein -
HVW68_RS21625 4558852..4559145 - 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
HVW68_RS21630 4559242..4559607 - 366 WP_003841415.1 hypothetical protein -
HVW68_RS21635 4559749..4559910 + 162 WP_003841416.1 phage protein -
HVW68_RS21640 4559998..4560786 - 789 WP_003844688.1 phosphotransferase -
HVW68_RS21645 4561101..4561418 + 318 Protein_4235 type II toxin-antitoxin system RelE/ParE family toxin -
HVW68_RS21650 4561411..4561689 + 279 WP_003844684.1 putative addiction module antidote protein -
HVW68_RS21655 4561699..4562016 - 318 WP_181825845.1 helix-turn-helix domain-containing protein Antitoxin
HVW68_RS21660 4562006..4562365 - 360 WP_032938228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVW68_RS21665 4562579..4563268 + 690 WP_003841421.1 dipeptidase PepE -
HVW68_RS21670 4563334..4564965 - 1632 WP_086529696.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13411.37 Da        Isoelectric Point: 10.3350

>T165738 WP_032938228.1 NZ_CP057864:c4562365-4562006 [Citrobacter freundii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKSLKGFGGAGVLEVVEDHHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

>T165738 NZ_CP073954:93505-93654 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11483.35 Da        Isoelectric Point: 6.9796

>AT165738 WP_181825845.1 NZ_CP057864:c4562016-4561699 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMMIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp

>AT165738 NZ_CP073954:c93458-93400 [Escherichia coli]
AGATACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MRN0

Antitoxin

Source ID Structure

References