Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4286035..4286551 Replicon chromosome
Accession NZ_CP057864
Organism Citrobacter freundii strain RHB12-C19

Toxin (Protein)


Gene name relE Uniprot ID A0A0J1MTE6
Locus tag HVW68_RS20360 Protein ID WP_016149473.1
Coordinates 4286035..4286319 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag HVW68_RS20365 Protein ID WP_003839576.1
Coordinates 4286309..4286551 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVW68_RS20345 4282360..4282944 + 585 WP_181825801.1 fructose PTS transporter subunit IIA -
HVW68_RS20350 4283322..4285460 + 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
HVW68_RS20355 4285567..4286031 + 465 WP_003839580.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVW68_RS20360 4286035..4286319 - 285 WP_016149473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVW68_RS20365 4286309..4286551 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVW68_RS20370 4286629..4288542 - 1914 WP_003844930.1 BglG family transcription antiterminator -
HVW68_RS20375 4288564..4289304 - 741 WP_003025772.1 KDGP aldolase family protein -
HVW68_RS20380 4289301..4290419 - 1119 WP_048219848.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
HVW68_RS20385 4290403..4291536 - 1134 WP_181825802.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10878.73 Da        Isoelectric Point: 10.0482

>T165737 WP_016149473.1 NZ_CP057864:c4286319-4286035 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

>T165737 NZ_CP073954:c80793-80395 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACCATCAAAAATAAACCAGCGCATATCCGGGAGCGTTTCAA
TCTGAATACAGGGCGAATGTGCATCAGCTCAGTGACCGTGATGGAACTGGTATACGGTGCTGAAAAAAGTCAGTTTCCGG
AGCGTAATCTCGCGATTATCGAAGGATTTATTTCGCGTCTTGACGTGCTGGATTACGACTGCGCTGCTGCCACACATACC
GGTCAGATCCGTGCTGAGCTCGCCCGTCAGGGACGTCCGGTGGGACCATTTGACCAGATGATTGCCGGTCATGCCCGCAG
CCGGGGACTCATTGTGGTCACAAACAATACCCGGGAGTTTGAACGTATCGCCGGCCTTCGTCTGGAAGACTGGTGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT165737 WP_003839576.1 NZ_CP057864:c4286551-4286309 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp

>AT165737 NZ_CP073954:c81020-80793 [Escherichia coli]
ATGGAAACGACCGTATTTCTCAGTAACCGGAGTCAGGCAGTCAGGCTGCCGAAGGCTGTAGCCCTGCCTGAAGACGTAAA
AAAAGTCGACGTTATTGCTGTTGGCCGTACCCGGATCATTACTCCGGCAGGAGAGTCCTGGGACAGCTGGTTCGATGGCG
ACAGTGTCAGCGCAGATTTCATGAATGACAGAGAACAACCCGCCGTACAGGAAAGGGACGCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MTE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References