Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2364878..2365517 Replicon chromosome
Accession NZ_CP057864
Organism Citrobacter freundii strain RHB12-C19

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HVW68_RS11310 Protein ID WP_071684398.1
Coordinates 2364878..2365054 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HVW68_RS11315 Protein ID WP_123924900.1
Coordinates 2365101..2365517 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVW68_RS11290 2361656..2361886 - 231 WP_003020233.1 DUF2554 family protein -
HVW68_RS11295 2362076..2362201 - 126 WP_003020230.1 DUF2474 domain-containing protein -
HVW68_RS11300 2362201..2363211 - 1011 WP_181826183.1 cytochrome d ubiquinol oxidase subunit II -
HVW68_RS11305 2363211..2364614 - 1404 WP_003843730.1 cytochrome ubiquinol oxidase subunit I -
HVW68_RS11310 2364878..2365054 + 177 WP_071684398.1 type II toxin-antitoxin system HicA family toxin Toxin
HVW68_RS11315 2365101..2365517 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HVW68_RS11320 2365610..2367019 + 1410 WP_044702348.1 PLP-dependent aminotransferase family protein -
HVW68_RS11325 2367347..2368492 + 1146 WP_003020212.1 ABC transporter substrate-binding protein -
HVW68_RS11330 2368509..2369525 + 1017 WP_058842662.1 ABC transporter ATP-binding protein -
HVW68_RS11335 2369526..2370470 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.86 Da        Isoelectric Point: 11.6208

>T165734 WP_071684398.1 NZ_CP057864:2364878-2365054 [Citrobacter freundii]
VKQSKFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

>T165734 NZ_CP073953:4340118-4340495 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT165734 WP_123924900.1 NZ_CP057864:2365101-2365517 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp

>AT165734 NZ_CP073953:4339697-4340071 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References