Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4581417..4581933 Replicon chromosome
Accession NZ_CP057722
Organism Klebsiella pneumoniae strain RHB16-C24

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HVX23_RS22170 Protein ID WP_009309309.1
Coordinates 4581417..4581701 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HVX23_RS22175 Protein ID WP_002886901.1
Coordinates 4581691..4581933 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX23_RS22145 4576834..4577142 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
HVX23_RS22150 4577227..4577400 + 174 WP_181812996.1 hypothetical protein -
HVX23_RS22155 4577403..4578146 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HVX23_RS22160 4578503..4580641 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HVX23_RS22165 4580949..4581413 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVX23_RS22170 4581417..4581701 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX23_RS22175 4581691..4581933 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVX23_RS22180 4582011..4583921 - 1911 WP_009486549.1 BglG family transcription antiterminator -
HVX23_RS22185 4583944..4585098 - 1155 WP_181812997.1 lactonase family protein -
HVX23_RS22190 4585165..4585905 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T165716 WP_009309309.1 NZ_CP057722:c4581701-4581417 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T165716 NZ_CP073953:194913-195020 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT165716 WP_002886901.1 NZ_CP057722:c4581933-4581691 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT165716 NZ_CP073953:c194856-194799 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References