Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1165066..1165785 Replicon chromosome
Accession NZ_CP057722
Organism Klebsiella pneumoniae strain RHB16-C24

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HVX23_RS05715 Protein ID WP_181813103.1
Coordinates 1165066..1165386 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HVX23_RS05720 Protein ID WP_097749805.1
Coordinates 1165420..1165785 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX23_RS05690 1160150..1161325 - 1176 WP_181813102.1 multidrug efflux RND transporter periplasmic adaptor subunit OqxA -
HVX23_RS05695 1161659..1162021 + 363 WP_002914181.1 helix-turn-helix domain-containing protein -
HVX23_RS05700 1162032..1162604 - 573 WP_004212922.1 flavin reductase -
HVX23_RS05705 1162816..1163700 + 885 WP_002914178.1 LysR family transcriptional regulator -
HVX23_RS05710 1163825..1164625 + 801 WP_004180956.1 hypothetical protein -
HVX23_RS05715 1165066..1165386 - 321 WP_181813103.1 TA system toxin CbtA family protein Toxin
HVX23_RS05720 1165420..1165785 - 366 WP_097749805.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HVX23_RS05725 1165817..1166038 - 222 WP_004390417.1 DUF987 domain-containing protein -
HVX23_RS05730 1166047..1166517 - 471 WP_097749806.1 DNA repair protein RadC -
HVX23_RS05735 1166587..1167408 - 822 WP_097749807.1 DUF945 domain-containing protein -
HVX23_RS05740 1167483..1167911 - 429 WP_097749808.1 hypothetical protein -
HVX23_RS05745 1167947..1168126 - 180 WP_181813104.1 hypothetical protein -
HVX23_RS05750 1168177..1168980 - 804 WP_097749809.1 hypothetical protein -
HVX23_RS05755 1169000..1169434 - 435 WP_117037059.1 hypothetical protein -
HVX23_RS05760 1170021..1170656 + 636 WP_097749811.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(11-105)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12157.91 Da        Isoelectric Point: 6.2084

>T165703 WP_181813103.1 NZ_CP057722:c1165386-1165066 [Klebsiella pneumoniae]
MHISIVPATVPVSPRLSPVQIWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTTIDLLRARRATGLVHT

Download         Length: 321 bp

>T165703 NZ_CP073949:1952279-1952382 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13378.15 Da        Isoelectric Point: 5.0348

>AT165703 WP_097749805.1 NZ_CP057722:c1165785-1165420 [Klebsiella pneumoniae]
MQSTTLSGSSADNASCLQWGLERNITPCFGARLVQEGNRLYFLTDRAGFDGSFSDDEALCLDQVFPLMMKQLERMLTTGE
LAPRCQHCVTLHHNGLTCEADTLGSHGYVYIAIYPQSAVIR

Download         Length: 366 bp

>AT165703 NZ_CP073949:c1952420-1952149 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References