Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2135025..2135601 Replicon chromosome
Accession NZ_CP057692
Organism Escherichia fergusonii strain RHB17-C11

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag HVX29_RS10390 Protein ID WP_024256621.1
Coordinates 2135314..2135601 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag HVX29_RS10385 Protein ID WP_000063156.1
Coordinates 2135025..2135327 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX29_RS10365 2130839..2131351 + 513 WP_001175454.1 4-hydroxyphenylacetate 3-monooxygenase reductase subunit -
HVX29_RS10370 2131621..2133771 + 2151 WP_001314407.1 pyruvate/proton symporter BtsT -
HVX29_RS10375 2133821..2134024 + 204 WP_000467859.1 YbdD/YjiX family protein -
HVX29_RS10380 2134035..2134991 + 957 WP_001297640.1 GTPase -
HVX29_RS10385 2135025..2135327 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
HVX29_RS10390 2135314..2135601 - 288 WP_024256621.1 BrnT family toxin Toxin
HVX29_RS10395 2135757..2136491 - 735 WP_000208600.1 hypothetical protein -
HVX29_RS10400 2136754..2140266 + 3513 WP_000981390.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11267.72 Da        Isoelectric Point: 6.8816

>T165687 WP_024256621.1 NZ_CP057692:c2135601-2135314 [Escherichia fergusonii]
MPMEFEWDANKAKSNRVKHDIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T165687 NZ_CP073946:2759604-2759711 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT165687 WP_000063156.1 NZ_CP057692:c2135327-2135025 [Escherichia fergusonii]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT165687 NZ_CP073946:c2759554-2759491 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References