Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1763393..1764227 Replicon chromosome
Accession NZ_CP057692
Organism Escherichia fergusonii strain RHB17-C11

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag HVX29_RS08680 Protein ID WP_039025883.1
Coordinates 1763393..1763770 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag HVX29_RS08685 Protein ID WP_039025882.1
Coordinates 1763859..1764227 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX29_RS08650 1758546..1759754 + 1209 WP_001352368.1 IS4-like element ISVsa5 family transposase -
HVX29_RS08655 1759767..1759958 - 192 Protein_1697 DUF4102 domain-containing protein -
HVX29_RS08660 1760334..1761653 + 1320 WP_105284452.1 site-specific integrase -
HVX29_RS08665 1761746..1762594 - 849 WP_039025884.1 DUF4942 domain-containing protein -
HVX29_RS08670 1762691..1762888 - 198 WP_000772024.1 DUF957 domain-containing protein -
HVX29_RS08675 1762908..1763396 - 489 Protein_1701 hypothetical protein -
HVX29_RS08680 1763393..1763770 - 378 WP_039025883.1 type IV toxin-antitoxin system toxin CbtA Toxin
HVX29_RS08685 1763859..1764227 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HVX29_RS08690 1764277..1764921 - 645 WP_039025881.1 hypothetical protein -
HVX29_RS08695 1764936..1765157 - 222 WP_000692312.1 DUF987 domain-containing protein -
HVX29_RS08700 1765226..1765702 - 477 WP_001186745.1 RadC family protein -
HVX29_RS08705 1765717..1766202 - 486 WP_000214316.1 antirestriction protein -
HVX29_RS08710 1766293..1767111 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1745020..1778576 33556
- flank IS/Tn - - 1758546..1759754 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T165685 WP_039025883.1 NZ_CP057692:c1763770-1763393 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T165685 NZ_CP073946:2115161-2115264 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT165685 WP_039025882.1 NZ_CP057692:c1764227-1763859 [Escherichia fergusonii]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT165685 NZ_CP073946:c2115302-2115031 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References