Detailed information of TA system TA165655

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1822031..1822685
• Replicon: chromosome
• Accession: NZ_CP057681
• Organism: Escherichia fergusonii strain RHB18-C04

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: F0JPE9
• Locus tag: HVX35_RS08910
• Protein ID: WP_000244774.1
• Coordinates: 1822031..1822438 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HVX35_RS08915
• Protein ID: WP_059224144.1
• Coordinates: 1822419..1822685 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX35_RS08890	1817988..1819721	-	1734	WP_000813234.1	single-stranded-DNA-specific exonuclease RecJ	-
HVX35_RS08895	1819727..1820437	-	711	WP_104917537.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HVX35_RS08900	1820462..1821358	-	897	WP_000806645.1	site-specific tyrosine recombinase XerD	-
HVX35_RS08905	1821470..1821991	+	522	WP_001055874.1	flavodoxin FldB	-
HVX35_RS08910	1822031..1822438	-	408	WP_000244774.1	protein YgfX	Toxin
HVX35_RS08915	1822419..1822685	-	267	WP_059224144.1	FAD assembly factor SdhE	Antitoxin
HVX35_RS08920	1822937..1823917	+	981	WP_000886103.1	tRNA-modifying protein YgfZ	-
HVX35_RS08925	1823994..1824653	-	660	WP_000250283.1	hemolysin III family protein	-
HVX35_RS08930	1824817..1825128	-	312	WP_001182961.1	N(4)-acetylcytidine aminohydrolase	-
HVX35_RS08935	1825173..1826606	+	1434	WP_046083325.1	6-phospho-beta-glucosidase BglA	-
HVX35_RS08940	1826654..1827547	-	894	WP_000819362.1	transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16078.05 Da
• Isoelectric Point: 11.2511

>T165655 WP_000244774.1 NZ_CP057681:c1822438-1822031 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T165655 NZ_CP073943:c604305-603841 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGGCATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10575.17 Da
• Isoelectric Point: 5.1599

>AT165655 WP_059224144.1 NZ_CP057681:c1822685-1822419 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPVDAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT165655 NZ_CP073943:c604640-604305 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A0L6ZX35