Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3417811..3418333 Replicon chromosome
Accession NZ_CP057657
Organism Escherichia fergusonii strain RHB19-C05

Toxin (Protein)


Gene name relE Uniprot ID A0A7W3EN85
Locus tag HVX45_RS16600 Protein ID WP_046083069.1
Coordinates 3418043..3418333 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7LMQ7
Locus tag HVX45_RS16595 Protein ID WP_000212726.1
Coordinates 3417811..3418053 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX45_RS16575 3413728..3415101 + 1374 WP_001219809.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
HVX45_RS16580 3415184..3415735 - 552 WP_000166270.1 ribosome-associated protein -
HVX45_RS16585 3415829..3417181 + 1353 WP_001162171.1 metalloprotease PmbA -
HVX45_RS16590 3417234..3417620 + 387 WP_001232246.1 cytochrome b562 -
HVX45_RS16595 3417811..3418053 + 243 WP_000212726.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVX45_RS16600 3418043..3418333 + 291 WP_046083069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX45_RS16605 3418334..3418798 - 465 WP_001106232.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVX45_RS16610 3418956..3421094 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
HVX45_RS16615 3421488..3423143 - 1656 WP_046083068.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T165631 WP_046083069.1 NZ_CP057657:3418043-3418333 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T165631 NZ_CP073936:3737657-3737935 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9140.53 Da        Isoelectric Point: 5.1369

>AT165631 WP_000212726.1 NZ_CP057657:3417811-3418053 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRQLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT165631 NZ_CP073936:3737394-3737654 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EN85

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3HXN7

References