Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4010531..4011185 Replicon chromosome
Accession NZ_CP057632
Organism Citrobacter sp. RHB20-C15

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag HVX63_RS19195 Protein ID WP_044254016.1
Coordinates 4010531..4010938 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag HVX63_RS19200 Protein ID WP_042322123.1
Coordinates 4010919..4011185 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX63_RS19175 4006436..4008169 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
HVX63_RS19180 4008175..4008888 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVX63_RS19185 4008912..4009808 - 897 WP_181825116.1 site-specific tyrosine recombinase XerD -
HVX63_RS19190 4009909..4010430 + 522 WP_044254018.1 flavodoxin FldB -
HVX63_RS19195 4010531..4010938 - 408 WP_044254016.1 protein YgfX Toxin
HVX63_RS19200 4010919..4011185 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
HVX63_RS19205 4011442..4012422 + 981 WP_044254013.1 tRNA-modifying protein YgfZ -
HVX63_RS19210 4012503..4013162 - 660 WP_042999363.1 hemolysin III family protein -
HVX63_RS19215 4013325..4013636 - 312 WP_044254010.1 N(4)-acetylcytidine aminohydrolase -
HVX63_RS19220 4013689..4014417 + 729 WP_044254008.1 MurR/RpiR family transcriptional regulator -
HVX63_RS19225 4014537..4015970 + 1434 WP_044254006.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T165607 WP_044254016.1 NZ_CP057632:c4010938-4010531 [Citrobacter sp. RHB20-C15]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T165607 NZ_CP073932:2619673-2619780 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT165607 WP_042322123.1 NZ_CP057632:c4011185-4010919 [Citrobacter sp. RHB20-C15]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT165607 NZ_CP073932:c2619626-2619560 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References