Detailed information of TA system TA165597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2003114..2003933
• Replicon: chromosome
• Accession: NZ_CP057632
• Organism: Citrobacter sp. RHB20-C15

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A3S5G4N2
• Locus tag: HVX63_RS09560
• Protein ID: WP_043001077.1
• Coordinates: 2003114..2003371 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HVX63_RS09565
• Protein ID: WP_044258114.1
• Coordinates: 2003382..2003933 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX63_RS09535	1998920..1999825	-	906	WP_043001082.1	dihydrodipicolinate synthase family protein	-
HVX63_RS09540	1999830..2000618	-	789	WP_043001081.1	IclR family transcriptional regulator	-
HVX63_RS09545	2000854..2001645	+	792	WP_044258121.1	PhzF family phenazine biosynthesis protein	-
HVX63_RS09550	2002126..2002518	+	393	WP_044258118.1	VOC family protein	-
HVX63_RS09555	2002528..2002734	+	207	WP_044258115.1	tryptophan synthase subunit alpha	-
HVX63_RS09560	2003114..2003371	+	258	WP_043001077.1	YjhX family toxin	Toxin
HVX63_RS09565	2003382..2003933	+	552	WP_044258114.1	N-acetyltransferase	Antitoxin
HVX63_RS09570	2003985..2004731	+	747	WP_044258113.1	class I SAM-dependent methyltransferase	-
HVX63_RS09575	2005408..2005992	+	585	WP_044258110.1	hypothetical protein	-
HVX63_RS09580	2006303..2007427	-	1125	WP_043001073.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.00 Da
• Isoelectric Point: 11.1381

>T165597 WP_043001077.1 NZ_CP057632:2003114-2003371 [Citrobacter sp. RHB20-C15]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T165597 NZ_CP073932:843080-843487 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20365.25 Da
• Isoelectric Point: 6.0668

>AT165597 WP_044258114.1 NZ_CP057632:2003382-2003933 [Citrobacter sp. RHB20-C15]
MTTRNFTIHITDESDTNDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQEGNAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGRGVGGLLIRTGIEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGFPAPYPIAEEHKACWMMQSLSA
QPFDRAGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT165597 NZ_CP073932:842833-843099 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A3S5G4N2