Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 704643..705322 Replicon chromosome
Accession NZ_CP057632
Organism Citrobacter sp. RHB20-C15

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HVX63_RS03435 Protein ID WP_181825246.1
Coordinates 704981..705322 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HVX63_RS03430 Protein ID WP_181825245.1
Coordinates 704643..704960 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX63_RS03385 700001..700705 + 705 WP_047666967.1 WYL domain-containing protein -
HVX63_RS03390 700705..701274 + 570 WP_181825418.1 hypothetical protein -
HVX63_RS03395 701311..701763 + 453 WP_181825238.1 hypothetical protein -
HVX63_RS03400 701760..702209 + 450 WP_181825239.1 hypothetical protein -
HVX63_RS03405 702281..702511 + 231 WP_181825240.1 DUF905 domain-containing protein -
HVX63_RS03410 702609..703430 + 822 WP_181825241.1 DUF945 domain-containing protein -
HVX63_RS03415 703461..703904 + 444 WP_181825242.1 antirestriction protein -
HVX63_RS03420 703913..704395 + 483 WP_181825243.1 RadC family protein -
HVX63_RS03425 704404..704625 + 222 WP_181825244.1 DUF987 domain-containing protein -
HVX63_RS03430 704643..704960 + 318 WP_181825245.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HVX63_RS03435 704981..705322 + 342 WP_181825246.1 TA system toxin CbtA family protein Toxin
HVX63_RS03440 705656..706882 - 1227 WP_181825247.1 hypothetical protein -
HVX63_RS03445 706884..707915 - 1032 WP_181825248.1 tyrosine-type recombinase/integrase -
HVX63_RS03450 707915..708508 - 594 WP_181825249.1 helix-turn-helix domain-containing protein -
HVX63_RS03455 708616..708837 + 222 WP_181825250.1 regulator -
HVX63_RS03460 708868..709371 + 504 WP_181825251.1 phage regulatory CII family protein -
HVX63_RS03465 709381..709608 + 228 WP_044328540.1 DUF2724 domain-containing protein -
HVX63_RS03470 709598..710026 + 429 WP_181825252.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 685127..755669 70542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12935.83 Da        Isoelectric Point: 9.0057

>T165594 WP_181825246.1 NZ_CP057632:704981-705322 [Citrobacter sp. RHB20-C15]
MKPQPATTSRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGITLTDAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAIS

Download         Length: 342 bp

>T165594 NZ_CP073932:c629432-628968 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11837.50 Da        Isoelectric Point: 7.7480

>AT165594 WP_181825245.1 NZ_CP057632:704643-704960 [Citrobacter sp. RHB20-C15]
MSNTTWGLQRYITPRLGARLVQEGNRLHYLADRASITGKFSDPECLKLNVAFPHFISQLESMLTAGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT165594 NZ_CP073932:c629767-629432 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References