Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4009466..4010120 Replicon chromosome
Accession NZ_CP057630
Organism Citrobacter sp. RHB20-C16

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag HVX64_RS19195 Protein ID WP_044254016.1
Coordinates 4009466..4009873 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag HVX64_RS19200 Protein ID WP_042322123.1
Coordinates 4009854..4010120 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX64_RS19175 4005371..4007104 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
HVX64_RS19180 4007110..4007823 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVX64_RS19185 4007847..4008743 - 897 WP_181825116.1 site-specific tyrosine recombinase XerD -
HVX64_RS19190 4008844..4009365 + 522 WP_044254018.1 flavodoxin FldB -
HVX64_RS19195 4009466..4009873 - 408 WP_044254016.1 protein YgfX Toxin
HVX64_RS19200 4009854..4010120 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
HVX64_RS19205 4010377..4011357 + 981 WP_044254013.1 tRNA-modifying protein YgfZ -
HVX64_RS19210 4011438..4012097 - 660 WP_042999363.1 hemolysin III family protein -
HVX64_RS19215 4012260..4012571 - 312 WP_044254010.1 N(4)-acetylcytidine aminohydrolase -
HVX64_RS19220 4012624..4013352 + 729 WP_044254008.1 MurR/RpiR family transcriptional regulator -
HVX64_RS19225 4013472..4014905 + 1434 WP_044254006.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T165588 WP_044254016.1 NZ_CP057630:c4009873-4009466 [Citrobacter sp. RHB20-C16]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T165588 NZ_CP073929:3770111-3770389 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT165588 WP_042322123.1 NZ_CP057630:c4010120-4009854 [Citrobacter sp. RHB20-C16]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT165588 NZ_CP073929:3769848-3770108 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References