Detailed information of TA system TA165578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2002048..2002867
• Replicon: chromosome
• Accession: NZ_CP057630
• Organism: Citrobacter sp. RHB20-C16

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A3S5G4N2
• Locus tag: HVX64_RS09555
• Protein ID: WP_043001077.1
• Coordinates: 2002048..2002305 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HVX64_RS09560
• Protein ID: WP_044258114.1
• Coordinates: 2002316..2002867 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX64_RS09530	1997854..1998759	-	906	WP_043001082.1	dihydrodipicolinate synthase family protein	-
HVX64_RS09535	1998764..1999552	-	789	WP_043001081.1	IclR family transcriptional regulator	-
HVX64_RS09540	1999788..2000579	+	792	WP_044258121.1	PhzF family phenazine biosynthesis protein	-
HVX64_RS09545	2001060..2001452	+	393	WP_044258118.1	VOC family protein	-
HVX64_RS09550	2001462..2001668	+	207	WP_044258115.1	tryptophan synthase subunit alpha	-
HVX64_RS09555	2002048..2002305	+	258	WP_043001077.1	YjhX family toxin	Toxin
HVX64_RS09560	2002316..2002867	+	552	WP_044258114.1	N-acetyltransferase	Antitoxin
HVX64_RS09565	2002919..2003665	+	747	WP_044258113.1	class I SAM-dependent methyltransferase	-
HVX64_RS09570	2004342..2004926	+	585	WP_044258110.1	hypothetical protein	-
HVX64_RS09575	2005237..2006361	-	1125	WP_043001073.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.00 Da
• Isoelectric Point: 11.1381

>T165578 WP_043001077.1 NZ_CP057630:2002048-2002305 [Citrobacter sp. RHB20-C16]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTAVECYSREGLLLADCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QPDNR

Nucleotide

• Length: 258 bp

>T165578 NZ_CP073929:1837959-1838213 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20365.25 Da
• Isoelectric Point: 6.0668

>AT165578 WP_044258114.1 NZ_CP057630:2002316-2002867 [Citrobacter sp. RHB20-C16]
MTTRNFTIHITDESDTNDIREVETRAFGYSKEACLVASLLEDDTARPTLSLLARQEGNAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGRGVGGLLIRTGIEHLRSMGCQCVFVLGHATYYPRHGFEPCAGDKGFPAPYPIAEEHKACWMMQSLSA
QPFDRAGDIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT165578 NZ_CP073929:1837711-1837962 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A3S5G4N2