Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 703577..704256 Replicon chromosome
Accession NZ_CP057630
Organism Citrobacter sp. RHB20-C16

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HVX64_RS03425 Protein ID WP_181825246.1
Coordinates 703915..704256 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag HVX64_RS03420 Protein ID WP_181825245.1
Coordinates 703577..703894 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX64_RS03375 698935..699639 + 705 WP_047666967.1 WYL domain-containing protein -
HVX64_RS03380 699639..700208 + 570 WP_181825418.1 hypothetical protein -
HVX64_RS03385 700245..700697 + 453 WP_181825238.1 hypothetical protein -
HVX64_RS03390 700694..701143 + 450 WP_181825239.1 hypothetical protein -
HVX64_RS03395 701215..701445 + 231 WP_181825240.1 DUF905 domain-containing protein -
HVX64_RS03400 701543..702364 + 822 WP_181825241.1 DUF945 domain-containing protein -
HVX64_RS03405 702395..702838 + 444 WP_181825242.1 antirestriction protein -
HVX64_RS03410 702847..703329 + 483 WP_181825243.1 RadC family protein -
HVX64_RS03415 703338..703559 + 222 WP_181825244.1 DUF987 domain-containing protein -
HVX64_RS03420 703577..703894 + 318 WP_181825245.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HVX64_RS03425 703915..704256 + 342 WP_181825246.1 TA system toxin CbtA family protein Toxin
HVX64_RS03430 704590..705816 - 1227 WP_181825247.1 hypothetical protein -
HVX64_RS03435 705818..706849 - 1032 WP_181825248.1 tyrosine-type recombinase/integrase -
HVX64_RS03440 706849..707442 - 594 WP_181825249.1 helix-turn-helix domain-containing protein -
HVX64_RS03445 707550..707771 + 222 WP_181825250.1 regulator -
HVX64_RS03450 707802..708305 + 504 WP_181825251.1 phage regulatory CII family protein -
HVX64_RS03455 708315..708542 + 228 WP_044328540.1 DUF2724 domain-containing protein -
HVX64_RS03460 708532..708960 + 429 WP_181825252.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 698935..739735 40800


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12935.83 Da        Isoelectric Point: 9.0057

>T165575 WP_181825246.1 NZ_CP057630:703915-704256 [Citrobacter sp. RHB20-C16]
MKPQPATTSRAVKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGITLTDAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAIS

Download         Length: 342 bp

>T165575 NZ_CP073929:889285-889692 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11837.50 Da        Isoelectric Point: 7.7480

>AT165575 WP_181825245.1 NZ_CP057630:703577-703894 [Citrobacter sp. RHB20-C16]
MSNTTWGLQRYITPRLGARLVQEGNRLHYLADRASITGKFSDPECLKLNVAFPHFISQLESMLTAGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT165575 NZ_CP073929:889038-889304 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References