Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3299972..3300592 Replicon chromosome
Accession NZ_CP057620
Organism Citrobacter sp. RHB21-C01

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVX68_RS15840 Protein ID WP_001280991.1
Coordinates 3300374..3300592 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0V9JYC1
Locus tag HVX68_RS15835 Protein ID WP_042285841.1
Coordinates 3299972..3300346 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX68_RS15825 3295112..3296305 + 1194 WP_042285835.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVX68_RS15830 3296328..3299477 + 3150 WP_042285838.1 multidrug efflux RND transporter permease subunit -
HVX68_RS15835 3299972..3300346 + 375 WP_042285841.1 Hha toxicity modulator TomB Antitoxin
HVX68_RS15840 3300374..3300592 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVX68_RS15845 3300770..3301327 + 558 WP_042285845.1 maltose O-acetyltransferase -
HVX68_RS15850 3301435..3301905 + 471 WP_042285848.1 YlaC family protein -
HVX68_RS15855 3301953..3302093 - 141 WP_016537667.1 type B 50S ribosomal protein L36 -
HVX68_RS15860 3302096..3302356 - 261 WP_042285853.1 type B 50S ribosomal protein L31 -
HVX68_RS15865 3302535..3304085 + 1551 WP_181821859.1 EAL domain-containing protein -
HVX68_RS15870 3304125..3304478 - 354 WP_060569050.1 DUF1428 family protein -
HVX68_RS15875 3304559..3305155 - 597 WP_181821860.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T165572 WP_001280991.1 NZ_CP057620:3300374-3300592 [Citrobacter sp. RHB21-C01]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T165572 NZ_CP073929:c637975-637511 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14467.25 Da        Isoelectric Point: 4.7077

>AT165572 WP_042285841.1 NZ_CP057620:3299972-3300346 [Citrobacter sp. RHB21-C01]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWQKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165572 NZ_CP073929:c638310-637975 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9JYC1

References