Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 755745..756399 Replicon chromosome
Accession NZ_CP057620
Organism Citrobacter sp. RHB21-C01

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HVX68_RS03620 Protein ID WP_181822564.1
Coordinates 755992..756399 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9JTE1
Locus tag HVX68_RS03615 Protein ID WP_042292140.1
Coordinates 755745..756011 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX68_RS03590 750942..752375 - 1434 WP_181822561.1 6-phospho-beta-glucosidase -
HVX68_RS03595 752493..753221 - 729 WP_060569471.1 MurR/RpiR family transcriptional regulator -
HVX68_RS03600 753274..753585 + 312 WP_042292149.1 N(4)-acetylcytidine aminohydrolase -
HVX68_RS03605 753748..754407 + 660 WP_181822562.1 hemolysin III family protein -
HVX68_RS03610 754508..755488 - 981 WP_181822563.1 tRNA-modifying protein YgfZ -
HVX68_RS03615 755745..756011 + 267 WP_042292140.1 FAD assembly factor SdhE Antitoxin
HVX68_RS03620 755992..756399 + 408 WP_181822564.1 protein YgfX Toxin
HVX68_RS03625 756444..756965 - 522 WP_042292135.1 flavodoxin FldB -
HVX68_RS03630 757065..757961 + 897 WP_181823236.1 site-specific tyrosine recombinase XerD -
HVX68_RS03635 757985..758698 + 714 WP_181822565.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVX68_RS03640 758704..760437 + 1734 WP_181822566.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15928.91 Da        Isoelectric Point: 10.5720

>T165562 WP_181822564.1 NZ_CP057620:755992-756399 [Citrobacter sp. RHB21-C01]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEVKLLLDGRLRWQGR
EWTIVSAPWIIKTGMMLRLRSESGKRQHLWLAADSMDEAEWRDLCRLMLQQSMQR

Download         Length: 408 bp

>T165562 NZ_CP073926:2457821-2459143 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1496

>AT165562 WP_042292140.1 NZ_CP057620:755745-756011 [Citrobacter sp. RHB21-C01]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFVRLLECDDPDLFNWLMNHGKPADVELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT165562 NZ_CP073926:2457555-2457821 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9JTE1

References