Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelE-RHH |
Location | 1989..2536 | Replicon | plasmid pRHB23-C01_2 |
Accession | NZ_CP057566 | ||
Organism | Escherichia fergusonii strain RHB23-C01 |
Toxin (Protein)
Gene name | parE | Uniprot ID | - |
Locus tag | HVX91_RS21720 | Protein ID | WP_181812597.1 |
Coordinates | 2255..2536 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | - |
Locus tag | HVX91_RS21715 | Protein ID | WP_064773164.1 |
Coordinates | 1989..2258 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HVX91_RS21710 | 46..1077 | + | 1032 | WP_000907867.1 | replication initiation protein | - |
HVX91_RS21715 | 1989..2258 | + | 270 | WP_064773164.1 | hypothetical protein | Antitoxin |
HVX91_RS21720 | 2255..2536 | + | 282 | WP_181812597.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HVX91_RS21725 | 2600..3348 | + | 749 | Protein_3 | 3'-5' exonuclease | - |
HVX91_RS21730 | 3465..3947 | + | 483 | WP_181812598.1 | hypothetical protein | - |
HVX91_RS21735 | 4248..4595 | + | 348 | WP_000142449.1 | hypothetical protein | - |
HVX91_RS21740 | 4615..5205 | - | 591 | WP_181812599.1 | hypothetical protein | - |
HVX91_RS21745 | 5205..5462 | - | 258 | WP_000371887.1 | hypothetical protein | - |
HVX91_RS21750 | 5750..6871 | + | 1122 | WP_181812600.1 | DUF3800 domain-containing protein | - |
HVX91_RS21755 | 6914..7405 | - | 492 | WP_001090930.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..124527 | 124527 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10894.50 Da Isoelectric Point: 9.4120
>T165541 WP_181812597.1 NZ_CP057566:2255-2536 [Escherichia fergusonii]
MMDIFWTRLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHSHFVLVYEVDSQWGKV
YILRVLHTAQKWP
MMDIFWTRLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHSHFVLVYEVDSQWGKV
YILRVLHTAQKWP
Download Length: 282 bp
>T165541 NZ_CP073924:2742473-2742580 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10234.55 Da Isoelectric Point: 7.2057
>AT165541 WP_064773164.1 NZ_CP057566:1989-2258 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAEGRQQLERGDVLPHDIVESSAAAWRD
EMSRKVAGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAEGRQQLERGDVLPHDIVESSAAAWRD
EMSRKVAGK
Download Length: 270 bp
>AT165541 NZ_CP073924:c2742423-2742360 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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