Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1377811..1378436 Replicon chromosome
Accession NZ_CP057565
Organism Escherichia fergusonii strain RHB23-C01

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVX91_RS06535 Protein ID WP_000911329.1
Coordinates 1378038..1378436 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVX91_RS06530 Protein ID WP_000450524.1
Coordinates 1377811..1378038 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX91_RS06505 1373613..1374083 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVX91_RS06510 1374083..1374655 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVX91_RS06515 1374802..1375680 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVX91_RS06520 1375697..1376731 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVX91_RS06525 1376943..1377656 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVX91_RS06530 1377811..1378038 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVX91_RS06535 1378038..1378436 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVX91_RS06540 1378583..1379446 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HVX91_RS06545 1379461..1381476 + 2016 WP_181812365.1 tRNA cytosine(34) acetyltransferase TmcA -
HVX91_RS06550 1381550..1382248 + 699 WP_000679801.1 esterase -
HVX91_RS06555 1382341..1382541 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T165521 WP_000911329.1 NZ_CP057565:1378038-1378436 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T165521 NZ_CP073914:3933214-3933465 [Proteus terrae subsp. cibarius]
ATGAAAACGATAAATTATACAGAAGCAAGACAAAACTTAACTTCAATTATGAATGAAACAATTGATGATAGAGTACCCAT
CATGATCACAAGGCAAAAGGGTATTCCATGTGTTCTTTTATCTCTTGATGAATACCAAGCACTAGAAGAAACTGCCTATC
TGTTACGATCTCCAGCGAATGCGCGCCATTTGCTCGATTCTATTGATGAACTGAACCAAGGTAAAGGTATAGAAAAGGAT
ATAACGGAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT165521 WP_000450524.1 NZ_CP057565:1377811-1378038 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT165521 NZ_CP073914:3933462-3933716 [Proteus terrae subsp. cibarius]
ATGAAATTAATTTTTTCTGAGCAATCATGGAGTGATTATCTTTATTGGCAACAAATAGACAAGAAAATAATTAAACGCAT
TAACGAACTCATAAAAGATATTAAAAGAACACCGTTTAGCGGAATAGGTAAACCAGAGCCCTTGAAACATAATTTAGCAG
GTTTTTGGTCAAGACGGATCACTGATGAACATCGCCTTATCTACCGTATTACTGATTCCGCTATAGAAATTGCATCATGT
CGATACCACTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References