Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 63419..64020 Replicon plasmid pRHB23-C02_3
Accession NZ_CP057563
Organism Escherichia fergusonii strain RHB23-C02

Toxin (Protein)


Gene name doc Uniprot ID A0A7A7LY66
Locus tag HVX92_RS22700 Protein ID WP_001216036.1
Coordinates 63419..63799 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A765X875
Locus tag HVX92_RS22705 Protein ID WP_032271830.1
Coordinates 63799..64020 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX92_RS22675 58860..60344 - 1485 WP_000124159.1 hypothetical protein -
HVX92_RS22680 60344..61537 - 1194 WP_000219618.1 hypothetical protein -
HVX92_RS22685 61623..62075 - 453 WP_023352520.1 hypothetical protein -
HVX92_RS22690 62164..63207 - 1044 WP_032313385.1 DUF968 domain-containing protein -
HVX92_RS22695 63235..63414 - 180 WP_001448367.1 hypothetical protein -
HVX92_RS22700 63419..63799 - 381 WP_001216036.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HVX92_RS22705 63799..64020 - 222 WP_032271830.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HVX92_RS22710 64093..64482 - 390 WP_000506730.1 DNA repair protein -
HVX92_RS22715 64657..65229 + 573 WP_001133670.1 hypothetical protein -
HVX92_RS22720 65236..65487 - 252 WP_001667237.1 DNA polymerase III subunit theta -
HVX92_RS22725 66150..66500 - 351 WP_032313386.1 hypothetical protein -
HVX92_RS22730 66504..67436 - 933 WP_089621505.1 hypothetical protein -
HVX92_RS22735 67418..67792 - 375 WP_000988654.1 hypothetical protein -
HVX92_RS22740 67799..68092 - 294 WP_000269005.1 hypothetical protein -
HVX92_RS22745 68271..68504 - 234 WP_000516536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95926 95926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13613.39 Da        Isoelectric Point: 5.6343

>T165514 WP_001216036.1 NZ_CP057563:c63799-63419 [Escherichia fergusonii]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELVDLTVGAATGEISVSTVAATLRRLYGSAE

Download         Length: 381 bp

>T165514 NZ_CP073910:4073367-4073642 [Sphingobium phenoxybenzoativorans]
ATGCTGGCGCTCATCTGGCACCCGGAGGCGCTCGATGATCTTGAGAACATACTAGACTTCATAGAGGTTCAGAACCCGTC
CGCCGCCGGGCGGATCGGAGAGGCCATCCGCCATACTGCCGGCCAGCTACCCAACCATCCCTATATGTATCGCACAGGCC
GCGTGCCCGGCACACGCGAAGCCCTCGTCACGCCCAATTATATTCTCGTCTATCGCGTTGCCGCCCACGCCATAGAAATA
CTCGCCGTCAAACACACCCGCCAGCAATACCCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8161.16 Da        Isoelectric Point: 5.1106

>AT165514 WP_032271830.1 NZ_CP057563:c64020-63799 [Escherichia fergusonii]
MRSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT165514 NZ_CP073910:4073191-4073367 [Sphingobium phenoxybenzoativorans]
ATGACCAAGCTTACCTCCATCGAGTCCGAATTCGCGACGACCGAGGAAGCGGAAGCCTATGACGCGTGGTTCCGGGCCAC
TGTCGAGGCGCGGATGGCGTCGGACAAGCCGGGCATCCCCCATGACGAAGTTATGGCGCGGATGCAGGCCATCATTGACC
GGCGAAAACAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7A7LY66

Antitoxin

Source ID Structure
AlphaFold DB A0A765X875

References