Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1989..2536 Replicon plasmid pRHB23-C02_2
Accession NZ_CP057562
Organism Escherichia fergusonii strain RHB23-C02

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag HVX92_RS21725 Protein ID WP_181812597.1
Coordinates 2255..2536 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag HVX92_RS21720 Protein ID WP_064773164.1
Coordinates 1989..2258 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX92_RS21715 46..1077 + 1032 WP_000907867.1 replication initiation protein -
HVX92_RS21720 1989..2258 + 270 WP_064773164.1 hypothetical protein Antitoxin
HVX92_RS21725 2255..2536 + 282 WP_181812597.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVX92_RS21730 2600..3348 + 749 Protein_3 3'-5' exonuclease -
HVX92_RS21735 3465..3947 + 483 WP_181812598.1 hypothetical protein -
HVX92_RS21740 4248..4595 + 348 WP_000142449.1 hypothetical protein -
HVX92_RS21745 4615..5205 - 591 WP_181812599.1 hypothetical protein -
HVX92_RS21750 5205..5462 - 258 WP_000371887.1 hypothetical protein -
HVX92_RS21755 5750..6871 + 1122 WP_181812600.1 DUF3800 domain-containing protein -
HVX92_RS21760 6914..7405 - 492 WP_001090930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..124527 124527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10894.50 Da        Isoelectric Point: 9.4120

>T165509 WP_181812597.1 NZ_CP057562:2255-2536 [Escherichia fergusonii]
MMDIFWTRLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHSHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T165509 NZ_CP073908:53341-53811 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10234.55 Da        Isoelectric Point: 7.2057

>AT165509 WP_064773164.1 NZ_CP057562:1989-2258 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAEGRQQLERGDVLPHDIVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT165509 NZ_CP073908:52901-53344 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References