Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1377812..1378437 Replicon chromosome
Accession NZ_CP057561
Organism Escherichia fergusonii strain RHB23-C02

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVX92_RS06535 Protein ID WP_000911329.1
Coordinates 1378039..1378437 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVX92_RS06530 Protein ID WP_000450524.1
Coordinates 1377812..1378039 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX92_RS06505 1373614..1374084 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVX92_RS06510 1374084..1374656 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVX92_RS06515 1374803..1375681 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVX92_RS06520 1375698..1376732 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVX92_RS06525 1376944..1377657 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVX92_RS06530 1377812..1378039 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVX92_RS06535 1378039..1378437 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVX92_RS06540 1378584..1379447 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HVX92_RS06545 1379462..1381477 + 2016 WP_181812365.1 tRNA cytosine(34) acetyltransferase TmcA -
HVX92_RS06550 1381551..1382249 + 699 WP_000679801.1 esterase -
HVX92_RS06555 1382342..1382542 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T165489 WP_000911329.1 NZ_CP057561:1378039-1378437 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T165489 NZ_CP073904:682162-682371 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT165489 WP_000450524.1 NZ_CP057561:1377812-1378039 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT165489 NZ_CP073904:681862-682155 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References