Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4374263..4374848 Replicon chromosome
Accession NZ_CP057509
Organism Citrobacter freundii strain RHB24-C03

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HVY04_RS20590 Protein ID WP_181819782.1
Coordinates 4374263..4374577 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HVY04_RS20595 Protein ID WP_115259723.1
Coordinates 4374570..4374848 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY04_RS20565 4370376..4371962 + 1587 WP_181819781.1 RNA repair transcriptional activator RtcR -
HVY04_RS20570 4372062..4372334 + 273 WP_096758747.1 DUF3811 domain-containing protein -
HVY04_RS20575 4372331..4373206 - 876 WP_096758748.1 23S rRNA pseudouridine(2604) synthase RluF -
HVY04_RS20580 4373457..4373774 - 318 WP_117343617.1 CcdB family protein -
HVY04_RS20585 4373774..4374067 - 294 WP_117343618.1 type II toxin-antitoxin system CcdA family antitoxin -
HVY04_RS20590 4374263..4374577 + 315 WP_181819782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY04_RS20595 4374570..4374848 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HVY04_RS20600 4374960..4375649 + 690 WP_115259724.1 dipeptidase PepE -
HVY04_RS20605 4375778..4377409 - 1632 WP_096758756.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11983.91 Da        Isoelectric Point: 9.5570

>T165482 WP_181819782.1 NZ_CP057509:4374263-4374577 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDIKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T165482 NZ_CP073898:2312910-2313098 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT165482 WP_115259723.1 NZ_CP057509:4374570-4374848 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT165482 NZ_CP073898:2312628-2312885 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References