Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3826584..3827238 Replicon chromosome
Accession NZ_CP057509
Organism Citrobacter freundii strain RHB24-C03

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HVY04_RS18035 Protein ID WP_096755799.1
Coordinates 3826584..3826991 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HVY04_RS18040 Protein ID WP_096755798.1
Coordinates 3826972..3827238 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY04_RS18015 3822532..3824265 - 1734 WP_115257543.1 single-stranded-DNA-specific exonuclease RecJ -
HVY04_RS18020 3824271..3824984 - 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY04_RS18025 3825008..3825904 - 897 WP_096755801.1 site-specific tyrosine recombinase XerD -
HVY04_RS18030 3826017..3826538 + 522 WP_096755800.1 flavodoxin FldB -
HVY04_RS18035 3826584..3826991 - 408 WP_096755799.1 protein YgfX Toxin
HVY04_RS18040 3826972..3827238 - 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HVY04_RS18045 3827495..3828475 + 981 WP_115257540.1 tRNA-modifying protein YgfZ -
HVY04_RS18050 3828555..3829214 - 660 WP_096755796.1 hemolysin III family protein -
HVY04_RS18055 3829378..3829689 - 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
HVY04_RS18060 3829742..3830470 + 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HVY04_RS18065 3830591..3832024 + 1434 WP_181819688.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T165480 WP_096755799.1 NZ_CP057509:c3826991-3826584 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T165480 NZ_CP057509:c3826991-3826584 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAGTGGATTTCGTTGCTCATTCATGGGCTAGTGGCGGT
GCTTATTTTATTGATGCCATGGCCACTGAGTTACACCCCTTTATGGTTGATTTTGCTCTCTCTGGTGGTGTTCGATTGCG
TGCGCAGTCAGCGCCGTATCAACGCTTGTCAGGGAGAGATTAGACTATTGATGGATGGCCGCCTGCGTTGGCAAGGGCAA
GAGTGGTCGATTGTTAGCGCCCCCTGGATGATAAAAACGGGCATGATGTTGCGTTTGCGGTCAAGTACAGGAAAGCGTCA
GCATCTGTGGCTGGCGGCGGACAGTATGGATGATGCCGAATGGCGGGATTTGCGTCGGTTGATATTACAACCGTCAATGC
AGAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT165480 WP_096755798.1 NZ_CP057509:c3827238-3826972 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165480 NZ_CP057509:c3827238-3826972 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATTTCGATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGATGACGAAAAGCGCATTTTTATCCGTTTGCTGGAATGTGATGACCCCGATT
TATTTAACTGGTTGATGAATCACGGGAAGCCGGCTGATGCACAGCTGGAGCAAATGGTACGGCTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References