165465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4378987..4379572 Replicon chromosome
Accession NZ_CP057506
Organism Citrobacter freundii strain RHB24-C05

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HVY06_RS20610 Protein ID WP_181819782.1
Coordinates 4378987..4379301 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HVY06_RS20615 Protein ID WP_115259723.1
Coordinates 4379294..4379572 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY06_RS20585 4375100..4376686 + 1587 WP_181819781.1 RNA repair transcriptional activator RtcR -
HVY06_RS20590 4376786..4377058 + 273 WP_096758747.1 DUF3811 domain-containing protein -
HVY06_RS20595 4377055..4377930 - 876 WP_096758748.1 23S rRNA pseudouridine(2604) synthase RluF -
HVY06_RS20600 4378181..4378498 - 318 WP_117343617.1 CcdB family protein -
HVY06_RS20605 4378498..4378791 - 294 WP_117343618.1 type II toxin-antitoxin system CcdA family antitoxin -
HVY06_RS20610 4378987..4379301 + 315 WP_181819782.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY06_RS20615 4379294..4379572 + 279 WP_115259723.1 putative addiction module antidote protein Antitoxin
HVY06_RS20620 4379684..4380373 + 690 WP_115259724.1 dipeptidase PepE -
HVY06_RS20625 4380502..4382133 - 1632 WP_096758756.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11983.91 Da        Isoelectric Point: 9.5570

>T165465 WP_181819782.1 NZ_CP057506:4378987-4379301 [Citrobacter freundii]
MEILQTMVFQRWEQNLRDRRAKTLIATRLFRLANGLAGDIKPVGEGISEMRISYGPGYRIYFKQQGCHIIILLCGGDKSS
QANDITMAKMLARSLDYQEIRHHE

Download         Length: 315 bp

>T165465 NZ_CP073890:693229-693591 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9863.44 Da        Isoelectric Point: 6.3200

>AT165465 WP_115259723.1 NZ_CP057506:4379294-4379572 [Citrobacter freundii]
MNKLTRYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIELTLKK

Download         Length: 279 bp

>AT165465 NZ_CP073890:693062-693232 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References