Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2314224..2314993 Replicon chromosome
Accession NZ_CP057506
Organism Citrobacter freundii strain RHB24-C05

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HVY06_RS11205 Protein ID WP_137400129.1
Coordinates 2314224..2314706 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HVY06_RS11210 Protein ID WP_174360861.1
Coordinates 2314697..2314993 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY06_RS11175 2309434..2310225 - 792 WP_181820304.1 carboxymuconolactone decarboxylase family protein -
HVY06_RS11180 2310250..2310473 - 224 Protein_2186 hypothetical protein -
HVY06_RS11185 2310498..2311547 - 1050 WP_181820305.1 NAD(P)-dependent alcohol dehydrogenase -
HVY06_RS11190 2311998..2312282 + 285 Protein_2188 aldo/keto reductase -
HVY06_RS11195 2312317..2313210 - 894 WP_146716824.1 LysR family transcriptional regulator -
HVY06_RS11200 2313359..2314123 + 765 WP_181820306.1 SDR family oxidoreductase -
HVY06_RS11205 2314224..2314706 - 483 WP_137400129.1 GNAT family N-acetyltransferase Toxin
HVY06_RS11210 2314697..2314993 - 297 WP_174360861.1 DUF1778 domain-containing protein Antitoxin
HVY06_RS11215 2315106..2317088 - 1983 WP_117342783.1 MBL fold metallo-hydrolase -
HVY06_RS11220 2317397..2318026 - 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HVY06_RS11225 2318306..2319493 - 1188 WP_146716827.1 outer membrane protein transport protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(26-148)

Antitoxin

Vibrio phage ICP1, Orf50

(5-97)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17739.36 Da        Isoelectric Point: 7.8963

>T165453 WP_137400129.1 NZ_CP057506:c2314706-2314224 [Citrobacter freundii]
MEINVTAPALLTEGHELQPFDCGNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSFGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T165453 NZ_CP073883:c180675-180487 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11545.13 Da        Isoelectric Point: 5.8990

>AT165453 WP_174360861.1 NZ_CP057506:c2314993-2314697 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDTRYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT165453 NZ_CP073883:c180957-180700 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References