Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3196661..3197280 Replicon chromosome
Accession NZ_CP057505
Organism Escherichia fergusonii strain RHB24-C06

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVY07_RS15150 Protein ID WP_001280991.1
Coordinates 3197062..3197280 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVY07_RS15145 Protein ID WP_000344803.1
Coordinates 3196661..3197035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY07_RS15135 3191793..3192986 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVY07_RS15140 3193009..3196158 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVY07_RS15145 3196661..3197035 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVY07_RS15150 3197062..3197280 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVY07_RS15155 3197777..3198247 + 471 WP_002431406.1 YlaC family protein -
HVY07_RS15160 3198386..3199936 + 1551 WP_181587816.1 EAL domain-containing protein -
HVY07_RS15165 3199978..3200331 - 354 WP_181673505.1 DUF1428 domain-containing protein -
HVY07_RS15175 3200710..3201021 + 312 WP_000409907.1 MGMT family protein -
HVY07_RS15180 3201052..3201624 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T165438 WP_001280991.1 NZ_CP057505:3197062-3197280 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T165438 NZ_CP073876:c1688402-1688223 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT165438 WP_000344803.1 NZ_CP057505:3196661-3197035 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165438 NZ_CP073876:c1689025-1688426 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References