Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3507887..3508541 Replicon chromosome
Accession NZ_CP057504
Organism Escherichia fergusonii strain RHB24-C08

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag HVY08_RS16700 Protein ID WP_000244774.1
Coordinates 3507887..3508294 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVY08_RS16705 Protein ID WP_000354046.1
Coordinates 3508275..3508541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY08_RS16680 3503844..3505577 - 1734 WP_181673588.1 single-stranded-DNA-specific exonuclease RecJ -
HVY08_RS16685 3505583..3506293 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY08_RS16690 3506318..3507214 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HVY08_RS16695 3507326..3507847 + 522 WP_001055874.1 flavodoxin FldB -
HVY08_RS16700 3507887..3508294 - 408 WP_000244774.1 protein YgfX Toxin
HVY08_RS16705 3508275..3508541 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVY08_RS16710 3508793..3509773 + 981 WP_181587863.1 tRNA-modifying protein YgfZ -
HVY08_RS16715 3509969..3510628 - 660 WP_000250283.1 hemolysin III family protein -
HVY08_RS16720 3510792..3511103 - 312 WP_001182961.1 N(4)-acetylcytidine aminohydrolase -
HVY08_RS16725 3511148..3512581 + 1434 WP_024256637.1 6-phospho-beta-glucosidase BglA -
HVY08_RS16730 3512629..3513522 - 894 WP_105284375.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T165418 WP_000244774.1 NZ_CP057504:c3508294-3507887 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T165418 NZ_CP073863:c1691009-1690830 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT165418 WP_000354046.1 NZ_CP057504:c3508541-3508275 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165418 NZ_CP073863:c1691632-1691033 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References