Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4041077..4041665 Replicon chromosome
Accession NZ_CP057483
Organism Citrobacter sp. RHB25-C09

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HVY19_RS19140 Protein ID WP_181682173.1
Coordinates 4041077..4041394 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HVY19_RS19145 Protein ID WP_181682174.1
Coordinates 4041387..4041665 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY19_RS19105 4036149..4036946 + 798 WP_181682167.1 PTS mannose/fructose/sorbose transporter subunit IIC -
HVY19_RS19110 4036958..4037782 + 825 WP_181682168.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HVY19_RS19115 4037834..4039054 + 1221 WP_181682169.1 L-sorbose 1-phosphate reductase -
HVY19_RS19120 4039105..4039476 - 372 WP_181682170.1 hypothetical protein -
HVY19_RS19125 4039618..4039779 + 162 WP_181682171.1 hypothetical protein -
HVY19_RS19130 4039907..4040206 + 300 WP_087603053.1 hypothetical protein -
HVY19_RS19135 4040307..4040708 + 402 WP_181682172.1 hypothetical protein -
HVY19_RS19140 4041077..4041394 + 318 WP_181682173.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY19_RS19145 4041387..4041665 + 279 WP_181682174.1 putative addiction module antidote protein Antitoxin
HVY19_RS19150 4041780..4042469 + 690 WP_181682175.1 dipeptidase PepE -
HVY19_RS19155 4042568..4044196 - 1629 WP_181682176.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11887.71 Da        Isoelectric Point: 9.8180

>T165404 WP_181682173.1 NZ_CP057483:4041077-4041394 [Citrobacter sp. RHB25-C09]
MMEILQTSVFQRWERNLKDRRAKTLIASRLFRVANGLAGDVRPVGEGISELRIHYGPGYRIYFKQHGDAIIILLCGGDKS
SQKSDIALAKIIDNTLNYKEIASHE

Download         Length: 318 bp

>T165404 NZ_CP073857:c1890970-1890575 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9664.14 Da        Isoelectric Point: 4.9987

>AT165404 WP_181682174.1 NZ_CP057483:4041387-4041665 [Citrobacter sp. RHB25-C09]
MNKLTQYDPAAALVDDDEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSDKGNPTLKTTLAV
MKALGIGLTVKT

Download         Length: 279 bp

>AT165404 NZ_CP073857:c1891200-1890970 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References