Detailed information of TA system TA165402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3774403..3774919
• Replicon: chromosome
• Accession: NZ_CP057483
• Organism: Citrobacter sp. RHB25-C09

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HVY19_RS17820
• Protein ID: WP_181681847.1
• Coordinates: 3774403..3774687 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HVY19_RS17825
• Protein ID: WP_181681849.1
• Coordinates: 3774677..3774919 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY19_RS17805	3769522..3771177	+	1656	WP_181681841.1	alpha,alpha-phosphotrehalase	-
HVY19_RS17810	3771577..3773715	+	2139	WP_181681843.1	anaerobic ribonucleoside-triphosphate reductase	-
HVY19_RS17815	3773930..3774394	+	465	WP_181681845.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HVY19_RS17820	3774403..3774687	-	285	WP_181681847.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HVY19_RS17825	3774677..3774919	-	243	WP_181681849.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HVY19_RS17830	3774997..3776907	-	1911	WP_181681851.1	BglG family transcription antiterminator	-
HVY19_RS17835	3776924..3777664	-	741	WP_181681853.1	KDGP aldolase family protein	-
HVY19_RS17840	3777661..3778779	-	1119	WP_181681855.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
HVY19_RS17845	3778763..3779896	-	1134	WP_181681857.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11013.85 Da
• Isoelectric Point: 10.1981

>T165402 WP_181681847.1 NZ_CP057483:c3774687-3774403 [Citrobacter sp. RHB25-C09]
MSYELEFDPRALKEWQKLGDNVKNQFKKKLAEVLINPRIESARLHGLPDCYKITLKSLGYRLVYRVQDEVVTVFVIATGK
REKSAVYQIADKRR

Nucleotide

• Length: 285 bp

>T165402 NZ_CP073855:2245954-2246142 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9095.53 Da
• Isoelectric Point: 6.3287

>AT165402 WP_181681849.1 NZ_CP057483:c3774919-3774677 [Citrobacter sp. RHB25-C09]
MATINVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTLSDNEEALLQTVRERLANPQKGVKVRLDEL

Nucleotide

• Length: 243 bp

>AT165402 NZ_CP073855:2245672-2245929 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA