Detailed information of TA system TA165401

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3646623..3647277
• Replicon: chromosome
• Accession: NZ_CP057483
• Organism: Citrobacter sp. RHB25-C09

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HVY19_RS17200
• Protein ID: WP_181681689.1
• Coordinates: 3646623..3647030 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HVY19_RS17205
• Protein ID: WP_181681690.1
• Coordinates: 3647011..3647277 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY19_RS17180	3642579..3644312	-	1734	WP_181681685.1	single-stranded-DNA-specific exonuclease RecJ	-
HVY19_RS17185	3644318..3645031	-	714	WP_181681686.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HVY19_RS17190	3645055..3645951	-	897	WP_181681687.1	site-specific tyrosine recombinase XerD	-
HVY19_RS17195	3646052..3646573	+	522	WP_181681688.1	flavodoxin FldB	-
HVY19_RS17200	3646623..3647030	-	408	WP_181681689.1	protein YgfX	Toxin
HVY19_RS17205	3647011..3647277	-	267	WP_181681690.1	FAD assembly factor SdhE	Antitoxin
HVY19_RS17210	3647534..3648514	+	981	WP_181681691.1	tRNA-modifying protein YgfZ	-
HVY19_RS17215	3648667..3649326	-	660	WP_181681692.1	hemolysin III family protein	-
HVY19_RS17220	3649486..3649797	-	312	WP_181681693.1	N(4)-acetylcytidine aminohydrolase	-
HVY19_RS17225	3649895..3651328	+	1434	WP_181681694.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15747.70 Da
• Isoelectric Point: 10.5767

>T165401 WP_181681689.1 NZ_CP057483:c3647030-3646623 [Citrobacter sp. RHB25-C09]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEVKLLMDGRLRWHGR
DWSIVSAPWIIKSGMMLRLRSDTGKRQHLWLAADSMDQTEWRDLCRLMLQPSTLG

Nucleotide

• Length: 408 bp

>T165401 NZ_CP073855:c2031356-2031147 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 5.1496

>AT165401 WP_181681690.1 NZ_CP057483:c3647277-3647011 [Citrobacter sp. RHB25-C09]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVKLIQTRN
RDRGPVAI

Nucleotide

• Length: 267 bp

>AT165401 NZ_CP073855:c2031656-2031363 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA