Detailed information of TA system TA165400

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3366121..3366796
• Replicon: chromosome
• Accession: NZ_CP057483
• Organism: Citrobacter sp. RHB25-C09

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HVY19_RS15930
• Protein ID: WP_181681467.1
• Coordinates: 3366476..3366796 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HVY19_RS15925
• Protein ID: WP_181681466.1
• Coordinates: 3366121..3366444 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY19_RS15905	3363351..3364115	-	765	WP_181681462.1	hypothetical protein	-
HVY19_RS15910	3364546..3365364	+	819	WP_181681463.1	DUF945 domain-containing protein	-
HVY19_RS15915	3365397..3365870	+	474	WP_181681464.1	DNA repair protein RadC	-
HVY19_RS15920	3365879..3366100	+	222	WP_181681465.1	DUF987 domain-containing protein	-
HVY19_RS15925	3366121..3366444	+	324	WP_181681466.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HVY19_RS15930	3366476..3366796	+	321	WP_181681467.1	TA system toxin CbtA family protein	Toxin
HVY19_RS15935	3367157..3368093	-	937	Protein_3118	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3367157..3367909	752

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12015.81 Da
• Isoelectric Point: 6.2084

>T165400 WP_181681467.1 NZ_CP057483:3366476-3366796 [Citrobacter sp. RHB25-C09]
MHISSVPAMVPVSSHLSPVQVWQQLLTYLLEHHYGLALNDTPLHDDAAIQEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKI

Nucleotide

• Length: 321 bp

>T165400 NZ_CP073855:c2020306-2019944 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11931.74 Da
• Isoelectric Point: 7.3237

>AT165400 WP_181681466.1 NZ_CP057483:3366121-3366444 [Citrobacter sp. RHB25-C09]
MQNSWGLKRDISPCFGARLVQEGCRLHFLADRAGISGAFNEEEALRLNKAFPLVMKQLELMLASGELNPRHQHCVTLYHN
GLTCEADTLGSHGYVYIVIYPQASAIK

Nucleotide

• Length: 324 bp

>AT165400 NZ_CP073855:c2020473-2020303 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA