Detailed information of TA system TA165391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1206465..1207084
• Replicon: chromosome
• Accession: NZ_CP057483
• Organism: Citrobacter sp. RHB25-C09

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: HVY19_RS05625
• Protein ID: WP_155106458.1
• Coordinates: 1206465..1206683 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: HVY19_RS05630
• Protein ID: WP_181683375.1
• Coordinates: 1206710..1207084 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY19_RS05600	1202340..1202936	+	597	WP_181683370.1	hypothetical protein	-
HVY19_RS05605	1203018..1203371	+	354	WP_181683371.1	DUF1428 family protein	-
HVY19_RS05610	1203411..1204961	-	1551	WP_181683372.1	EAL domain-containing protein	-
HVY19_RS05615	1205139..1205609	-	471	WP_181683373.1	YlaC family protein	-
HVY19_RS05620	1205712..1206275	-	564	WP_181683374.1	maltose O-acetyltransferase	-
HVY19_RS05625	1206465..1206683	-	219	WP_155106458.1	hemolysin expression modulator Hha	Toxin
HVY19_RS05630	1206710..1207084	-	375	WP_181683375.1	Hha toxicity modulator TomB	Antitoxin
HVY19_RS05635	1207585..1210734	-	3150	WP_181683376.1	efflux RND transporter permease AcrB	-
HVY19_RS05640	1210757..1211950	-	1194	WP_181683377.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8599.95 Da
• Isoelectric Point: 8.9008

>T165391 WP_155106458.1 NZ_CP057483:c1206683-1206465 [Citrobacter sp. RHB25-C09]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T165391 NZ_CP073850:822482-822877 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14544.38 Da
• Isoelectric Point: 4.8989

>AT165391 WP_181683375.1 NZ_CP057483:c1207084-1206710 [Citrobacter sp. RHB25-C09]
MDEYSPKRYDIAQLKFLCETLYHDCLANLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT165391 NZ_CP073850:822252-822482 [Staphylococcus epidermidis]
ATGATTACTACAAGAAAACTAAGAAAAGCTGGTAATAGTTCAGTTGTTTCTGTACCGACAGAAGTGATCGCAGCACTCGG
AATATCAAATGGTGATAATCTTAAATTTAATGTAAAAGATAATAAAGTAACCATCGAAAAGGAGGTAAGAGAGGACGAGG
AGTTTTTTAAATTGTTGGATGAAACATTCACTGAGTATAACCAAGCTTTAAAAAGGATGGTTGACTTATAA