Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1402791..1403416 Replicon chromosome
Accession NZ_CP057481
Organism Escherichia fergusonii strain RHB25-C10

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVY20_RS06650 Protein ID WP_000911329.1
Coordinates 1403018..1403416 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVY20_RS06645 Protein ID WP_000450524.1
Coordinates 1402791..1403018 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY20_RS06620 1398594..1399064 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVY20_RS06625 1399064..1399636 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVY20_RS06630 1399783..1400661 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVY20_RS06635 1400678..1401712 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVY20_RS06640 1401924..1402637 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVY20_RS06645 1402791..1403018 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVY20_RS06650 1403018..1403416 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVY20_RS06655 1403563..1404426 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HVY20_RS06660 1404441..1406456 + 2016 WP_181666116.1 tRNA cytosine(34) acetyltransferase TmcA -
HVY20_RS06665 1406530..1407228 + 699 WP_181666117.1 esterase -
HVY20_RS06670 1407321..1407521 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T165369 WP_000911329.1 NZ_CP057481:1403018-1403416 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T165369 NZ_CP073840:681051-681260 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT165369 WP_000450524.1 NZ_CP057481:1402791-1403018 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT165369 NZ_CP073840:680751-681044 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References