Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 775162..775712 Replicon chromosome
Accession NZ_CP057481
Organism Escherichia fergusonii strain RHB25-C10

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag HVY20_RS03830 Protein ID WP_001160963.1
Coordinates 775398..775712 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HVY20_RS03825 Protein ID WP_000125566.1
Coordinates 775162..775395 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY20_RS03800 770234..770521 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HVY20_RS03805 770580..771911 + 1332 WP_104919955.1 MFS transporter -
HVY20_RS03810 772019..772549 + 531 WP_000600726.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HVY20_RS03815 772542..774404 + 1863 WP_104919956.1 glutathione-regulated potassium-efflux system protein KefC -
HVY20_RS03820 774597..775076 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HVY20_RS03825 775162..775395 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HVY20_RS03830 775398..775712 + 315 WP_001160963.1 CcdB family protein Toxin
HVY20_RS03835 775709..776557 - 849 WP_000257189.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HVY20_RS03840 776564..776941 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HVY20_RS03845 776944..777765 - 822 WP_001065388.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HVY20_RS03850 777762..778751 - 990 WP_104918215.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HVY20_RS03855 778751..780037 - 1287 WP_104919957.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T165365 WP_001160963.1 NZ_CP057481:775398-775712 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T165365 NZ_CP073836:693330-693692 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT165365 WP_000125566.1 NZ_CP057481:775162-775395 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT165365 NZ_CP073836:693163-693333 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References