Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1985..2544 Replicon plasmid pRHB26-C03_2
Accession NZ_CP057464
Organism Escherichia fergusonii strain RHB26-C03

Toxin (Protein)


Gene name relE Uniprot ID A0A733EV64
Locus tag HVY27_RS22525 Protein ID WP_001582571.1
Coordinates 2269..2544 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag HVY27_RS22520 Protein ID WP_001178089.1
Coordinates 1985..2269 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY27_RS22515 46..1077 + 1032 WP_000907861.1 replication initiation protein -
HVY27_RS22520 1985..2269 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
HVY27_RS22525 2269..2544 + 276 WP_001582571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY27_RS22530 2650..2928 + 279 WP_001105069.1 hypothetical protein -
HVY27_RS22535 3123..3389 - 267 WP_000627829.1 hypothetical protein -
HVY27_RS22540 3389..3660 - 272 Protein_5 hypothetical protein -
HVY27_RS22545 3716..4318 - 603 WP_000517695.1 hypothetical protein -
HVY27_RS22550 4672..6018 + 1347 WP_115978218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..107745 107745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.48 Da        Isoelectric Point: 9.5296

>T165356 WP_001582571.1 NZ_CP057464:2269-2544 [Escherichia fergusonii]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNDQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T165356 NZ_CP073830:c2033608-2033399 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT165356 WP_001178089.1 NZ_CP057464:1985-2269 [Escherichia fergusonii]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT165356 NZ_CP073830:c2033908-2033615 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A733EV64

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References