Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3612236..3612786 Replicon chromosome
Accession NZ_CP057463
Organism Escherichia fergusonii strain RHB26-C03

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag HVY27_RS17820 Protein ID WP_001160963.1
Coordinates 3612472..3612786 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag HVY27_RS17815 Protein ID WP_000125566.1
Coordinates 3612236..3612469 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY27_RS17790 3607308..3607595 + 288 WP_000203741.1 ferredoxin-like protein FixX -
HVY27_RS17795 3607654..3608985 + 1332 WP_181198739.1 MFS transporter -
HVY27_RS17800 3609093..3609623 + 531 WP_000600701.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
HVY27_RS17805 3609616..3611478 + 1863 WP_104919956.1 glutathione-regulated potassium-efflux system protein KefC -
HVY27_RS17810 3611671..3612150 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
HVY27_RS17815 3612236..3612469 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HVY27_RS17820 3612472..3612786 + 315 WP_001160963.1 CcdB family protein Toxin
HVY27_RS17825 3612783..3613631 - 849 WP_000257179.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
HVY27_RS17830 3613638..3614015 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
HVY27_RS17835 3614018..3614839 - 822 WP_001065390.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
HVY27_RS17840 3614836..3615825 - 990 WP_046076786.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
HVY27_RS17845 3615825..3617111 - 1287 WP_181198740.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T165351 WP_001160963.1 NZ_CP057463:3612472-3612786 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T165351 NZ_CP073827:c2033135-2032926 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT165351 WP_000125566.1 NZ_CP057463:3612236-3612469 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT165351 NZ_CP073827:c2033435-2033142 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References