Detailed information of TA system TA165348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3422501..3423023
• Replicon: chromosome
• Accession: NZ_CP057463
• Organism: Escherichia fergusonii strain RHB26-C03

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HVY27_RS16805
• Protein ID: WP_181198684.1
• Coordinates: 3422733..3423023 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V0SC69
• Locus tag: HVY27_RS16800
• Protein ID: WP_000212715.1
• Coordinates: 3422501..3422743 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY27_RS16780	3418418..3419791	+	1374	WP_001219809.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
HVY27_RS16785	3419874..3420425	-	552	WP_000166270.1	ribosome-associated protein	-
HVY27_RS16790	3420519..3421871	+	1353	WP_001162164.1	metalloprotease PmbA	-
HVY27_RS16795	3421924..3422310	+	387	WP_001232246.1	cytochrome b562	-
HVY27_RS16800	3422501..3422743	+	243	WP_000212715.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HVY27_RS16805	3422733..3423023	+	291	WP_181198684.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HVY27_RS16810	3423024..3423488	-	465	WP_001106232.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HVY27_RS16815	3423646..3425784	-	2139	WP_046076417.1	anaerobic ribonucleoside-triphosphate reductase	-
HVY27_RS16820	3426178..3427833	-	1656	WP_046076416.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11324.16 Da
• Isoelectric Point: 10.0464

>T165348 WP_181198684.1 NZ_CP057463:3422733-3423023 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYEIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T165348 NZ_CP073827:c1690386-1690207 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9125.56 Da
• Isoelectric Point: 5.1369

>AT165348 WP_000212715.1 NZ_CP057463:3422501-3422743 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT165348 NZ_CP073827:c1691009-1690410 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U9H4B3