Detailed information of TA system TA165342

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1898278..1898932
• Replicon: chromosome
• Accession: NZ_CP057463
• Organism: Escherichia fergusonii strain RHB26-C03

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: F0JPE9
• Locus tag: HVY27_RS09465
• Protein ID: WP_000244774.1
• Coordinates: 1898278..1898685 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: HVY27_RS09470
• Protein ID: WP_059224144.1
• Coordinates: 1898666..1898932 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY27_RS09445	1894235..1895968	-	1734	WP_000813234.1	single-stranded-DNA-specific exonuclease RecJ	-
HVY27_RS09450	1895974..1896684	-	711	WP_104917537.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HVY27_RS09455	1896709..1897605	-	897	WP_000806645.1	site-specific tyrosine recombinase XerD	-
HVY27_RS09460	1897717..1898238	+	522	WP_001055874.1	flavodoxin FldB	-
HVY27_RS09465	1898278..1898685	-	408	WP_000244774.1	protein YgfX	Toxin
HVY27_RS09470	1898666..1898932	-	267	WP_059224144.1	FAD assembly factor SdhE	Antitoxin
HVY27_RS09475	1899184..1900164	+	981	WP_000886103.1	tRNA-modifying protein YgfZ	-
HVY27_RS09480	1900241..1900900	-	660	WP_000250283.1	hemolysin III family protein	-
HVY27_RS09485	1901064..1901375	-	312	WP_001182961.1	N(4)-acetylcytidine aminohydrolase	-
HVY27_RS09490	1901420..1902853	+	1434	WP_046083325.1	6-phospho-beta-glucosidase BglA	-
HVY27_RS09495	1902901..1903794	-	894	WP_000819362.1	transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 16078.05 Da
• Isoelectric Point: 11.2511

>T165342 WP_000244774.1 NZ_CP057463:c1898685-1898278 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Nucleotide

• Length: 408 bp

>T165342 NZ_CP073821:1024934-1025113 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10575.17 Da
• Isoelectric Point: 5.1599

>AT165342 WP_059224144.1 NZ_CP057463:c1898932-1898666 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPVDAELEMMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT165342 NZ_CP073821:1024311-1024910 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Structures

Toxin

• AlphaFold DB: A0A0L6ZX35