Detailed information of TA system TA165326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4978239..4979920
• Replicon: chromosome
• Accession: NZ_CP057459
• Organism: Klebsiella pneumoniae strain RHB26-C08

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: HVY29_RS24230
• Protein ID: WP_004146663.1
• Coordinates: 4978239..4979156 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: HVY29_RS24235
• Protein ID: WP_004177809.1
• Coordinates: 4979162..4979920 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY29_RS24210	4973545..4975065	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
HVY29_RS24215	4975062..4976060	+	999	WP_002885172.1	ribose ABC transporter permease	-
HVY29_RS24220	4976091..4977032	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HVY29_RS24225	4977107..4978114	+	1008	WP_009484222.1	carbohydrate kinase family protein	-
HVY29_RS24230	4978239..4979156	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HVY29_RS24235	4979162..4979920	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HVY29_RS24240	4980006..4980734	-	729	WP_002885152.1	response regulator transcription factor	-
HVY29_RS24245	4981007..4983154	+	2148	WP_181672677.1	formate dehydrogenase subunit alpha	-
HVY29_RS24250	4983616..4984302	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T165326 WP_004146663.1 NZ_CP057459:c4979156-4978239 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T165326 NZ_CP073808:c1172092-1171820 [Macrococcus canis]
ATGCCTAAGAAAAAGATACTATTTTATTCAAGTGGTTTTGAAGATTATACGTACTGGCAAACTAACGATAAAACTGTATT
AAAGAAAATAAATAAACTAATAAAGAGTATTATGATTGATGGTGCAAATAAAGGTATAGGTAAGCCAGAAAAATTATTAG
GAAACTATACAGGTTGCTATAGCAGAAGAATCACTCATGAACATAGGCTCGTATATAAGATAGAAGATGATTCAATTTGT
ATTTTACAATGTCGTTTTCATTATAAAAGGTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT165326 WP_004177809.1 NZ_CP057459:c4979920-4979162 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT165326 NZ_CP073808:c1172342-1172085 [Macrococcus canis]
ATGAAAGTCACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATAATAGATATTGTTAATGAAGACTGTGAACCTTA
CACAATCACAACAAATACGCATAATGCCGTGATATTATCTGAACAAGATTATAATAGTATGATTGAAACACTTTATTTAC
AGAGTACACCAGCGAATGCCGAAAGGTTACAAAAAGCGATAGATGAATCAACTGATAAAAATAACTTACTTCAAGTTGAG
ATAGATTTAGATGCCTAA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05