Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4818368..4818884 Replicon chromosome
Accession NZ_CP057459
Organism Klebsiella pneumoniae strain RHB26-C08

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HVY29_RS23420 Protein ID WP_004178374.1
Coordinates 4818368..4818652 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HVY29_RS23425 Protein ID WP_002886901.1
Coordinates 4818642..4818884 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY29_RS23395 4813785..4814093 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
HVY29_RS23400 4814178..4814351 + 174 WP_002886906.1 hypothetical protein -
HVY29_RS23405 4814354..4815097 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HVY29_RS23410 4815454..4817592 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HVY29_RS23415 4817900..4818364 + 465 WP_114261236.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVY29_RS23420 4818368..4818652 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVY29_RS23425 4818642..4818884 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVY29_RS23430 4818962..4820872 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HVY29_RS23435 4820895..4822049 - 1155 WP_004178372.1 lactonase family protein -
HVY29_RS23440 4822116..4822856 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T165325 WP_004178374.1 NZ_CP057459:c4818652-4818368 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T165325 NZ_CP073808:1168603-1168863 [Macrococcus canis]
ATGTACAAAATTGTAATGAAATCTAGTGTTAAGAAAGATTTAAAGAAGATTAAAAACACGCACTTAGAACCGAACTTTCT
AAAAATCATTAATCAGCTTAAAGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATCCCCCCAATAAAGGGAT
TTTATTCGAGAAGGATAAATGTACAACATCGTGTTGTTTATACTGTAAATGACGAAGATAAAATTGTAACAATTTATTCA
GCATATGGACATTATGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT165325 WP_002886901.1 NZ_CP057459:c4818884-4818642 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT165325 NZ_CP073808:1168352-1168603 [Macrococcus canis]
ATGAATACTTATACACCAACAAGTGCTAGAAAAGATTTTTTCAACATCATCAAATCTGTTAATGAAGATAGTAAAGAAAT
ATATATCGCACCAACTAAAGTTGGAGAAAAAGGTGCTGTTTTAGTCGGCGAAGATGATTGGAATGCTATTCAGGAAACTT
TATTCTTATTAGAAAAAGGTATCGCTTATCAAATTGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACTTGG
GATAATATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References