Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2716368..2717956 Replicon chromosome
Accession NZ_CP057459
Organism Klebsiella pneumoniae strain RHB26-C08

Toxin (Protein)


Gene name hipA Uniprot ID A0A486MZ73
Locus tag HVY29_RS13200 Protein ID WP_009485244.1
Coordinates 2716368..2717690 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HVY29_RS13205 Protein ID WP_002904790.1
Coordinates 2717690..2717956 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY29_RS13185 2711424..2713925 + 2502 WP_009485242.1 fimbrial biogenesis outer membrane usher protein -
HVY29_RS13190 2713913..2714917 + 1005 WP_009485243.1 type 1 fimbrial protein -
HVY29_RS13195 2715059..2716351 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HVY29_RS13200 2716368..2717690 - 1323 WP_009485244.1 type II toxin-antitoxin system HipA family toxin Toxin
HVY29_RS13205 2717690..2717956 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HVY29_RS13210 2718222..2718548 - 327 WP_009485245.1 hydroxyisourate hydrolase -
HVY29_RS13215 2718545..2719045 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HVY29_RS13220 2719023..2720402 - 1380 WP_004184021.1 purine permease -
HVY29_RS13225 2720748..2721902 + 1155 WP_009485247.1 FAD-dependent urate hydroxylase HpxO -
HVY29_RS13230 2721883..2722806 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49157.50 Da        Isoelectric Point: 7.5062

>T165322 WP_009485244.1 NZ_CP057459:c2717690-2716368 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T165322 NZ_CP073805:c1201680-1201408 [Macrococcus canis]
ATGACTAAGAAAAAGATACTATTTTATTCAAGTGGTTTTGAAGATTATACGTACTGGCAAACTAACGATAAAACTGTATT
AAAGAAAATAAATAAACTAATAAAGAGTATTATGATTGATGGTGCAAATGAAGGTATAGGTAAACCAGAAAAATTATTAG
GAAACTATACAGGTTGCTATAGCAGAAGGATAACTCATGAACATAGGCTCGTATATAAGATAGATGATGATTCAATTTGT
ATTTTACAATGTCGTTTTCATTATAAAAGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT165322 WP_002904790.1 NZ_CP057459:c2717956-2717690 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT165322 NZ_CP073805:c1201930-1201673 [Macrococcus canis]
ATGAAAGTCACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATAATAGATATTGTTAATGAAGACAGTGAACCTTA
CACAATCACAACAAACACTCATAATGCCGTGATATTATCTGAACAAGATTATAATAGTATGATTGAAACACTTTACTTAC
AGAGTACACCAGCGAATGCCGAAAGGTTACAAAAAGCGATTGATGAATCAATTGATAAAAATAACTTACTTCAAGTTGAG
ATTGATTTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486MZ73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References