Detailed information of TA system TA165279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3446419..3446941
• Replicon: chromosome
• Accession: NZ_CP057357
• Organism: Escherichia fergusonii strain RHB28-C21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HVY57_RS16605
• Protein ID: WP_104917776.1
• Coordinates: 3446651..3446941 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V0SC69
• Locus tag: HVY57_RS16600
• Protein ID: WP_000212715.1
• Coordinates: 3446419..3446661 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY57_RS16580	3442336..3443709	+	1374	WP_001219809.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
HVY57_RS16585	3443792..3444343	-	552	WP_000166270.1	ribosome-associated protein	-
HVY57_RS16590	3444437..3445789	+	1353	WP_001162157.1	metalloprotease PmbA	-
HVY57_RS16595	3445842..3446228	+	387	WP_001232246.1	cytochrome b562	-
HVY57_RS16600	3446419..3446661	+	243	WP_000212715.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HVY57_RS16605	3446651..3446941	+	291	WP_104917776.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HVY57_RS16610	3446942..3447406	-	465	WP_001106235.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HVY57_RS16615	3447564..3449702	-	2139	WP_000187805.1	anaerobic ribonucleoside-triphosphate reductase	-
HVY57_RS16620	3450096..3451751	-	1656	WP_104917775.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11307.26 Da
• Isoelectric Point: 10.2724

>T165279 WP_104917776.1 NZ_CP057357:3446651-3446941 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVKVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYQVNDKELIVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T165279 NZ_CP073788:808151-808561 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9125.56 Da
• Isoelectric Point: 5.1369

>AT165279 WP_000212715.1 NZ_CP057357:3446419-3446661 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT165279 NZ_CP073788:807904-808170 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9H4B3