Detailed information of TA system TA165264

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 949753..950588
• Replicon: chromosome
• Accession: NZ_CP057357
• Organism: Escherichia fergusonii strain RHB28-C21

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A7W4PV54
• Locus tag: HVY57_RS04770
• Protein ID: WP_000854821.1
• Coordinates: 949753..950130 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HVY57_RS04775
• Protein ID: WP_063266316.1
• Coordinates: 950220..950588 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY57_RS04730	945012..945494	-	483	WP_024256467.1	DUF1097 domain-containing protein	-
HVY57_RS04735	945595..946149	-	555	WP_104917373.1	molecular chaperone	-
HVY57_RS04740	946173..946910	-	738	WP_104917374.1	phosphatase	-
HVY57_RS04745	946997..947935	-	939	WP_000353197.1	glyoxylate/hydroxypyruvate reductase GhrA	-
HVY57_RS04755	948407..949249	-	843	WP_181673076.1	DUF4942 domain-containing protein	-
HVY57_RS04760	949334..949531	-	198	WP_023563519.1	DUF957 domain-containing protein	-
HVY57_RS04765	949559..949756	-	198	Protein_941	hypothetical protein	-
HVY57_RS04770	949753..950130	-	378	WP_000854821.1	type IV toxin-antitoxin system toxin CbtA	Toxin
HVY57_RS04775	950220..950588	-	369	WP_063266316.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
HVY57_RS04780	950638..951282	-	645	WP_059252084.1	hypothetical protein	-
HVY57_RS04785	951297..951518	-	222	WP_000692353.1	DUF987 domain-containing protein	-
HVY57_RS04790	951587..952063	-	477	WP_181673077.1	RadC family protein	-
HVY57_RS04795	952078..952563	-	486	WP_000214317.1	antirestriction protein	-
HVY57_RS04800	952654..953472	-	819	WP_001234702.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13930.95 Da
• Isoelectric Point: 8.5163

>T165264 WP_000854821.1 NZ_CP057357:c950130-949753 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T165264 NZ_CP073783:691864-692349 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTAATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13634.39 Da
• Isoelectric Point: 6.7386

>AT165264 WP_063266316.1 NZ_CP057357:c950588-950220 [Escherichia fergusonii]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLSSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT165264 NZ_CP073783:691574-691867 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A7W4PV54