Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3555722..3556342 Replicon chromosome
Accession NZ_CP057353
Organism Citrobacter freundii strain RHB29-C07

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HVY60_RS16935 Protein ID WP_002892050.1
Coordinates 3556124..3556342 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag HVY60_RS16930 Protein ID WP_115259201.1
Coordinates 3555722..3556096 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY60_RS16920 3550868..3552061 + 1194 WP_096758038.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVY60_RS16925 3552084..3555233 + 3150 WP_096758039.1 efflux RND transporter permease AcrB -
HVY60_RS16930 3555722..3556096 + 375 WP_115259201.1 Hha toxicity modulator TomB Antitoxin
HVY60_RS16935 3556124..3556342 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HVY60_RS16940 3556724..3557197 + 474 WP_096758041.1 YlaC family protein -
HVY60_RS16945 3557271..3557411 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
HVY60_RS16950 3557413..3557673 - 261 WP_115259215.1 type B 50S ribosomal protein L31 -
HVY60_RS16955 3557858..3559411 + 1554 WP_115259216.1 EAL domain-containing protein -
HVY60_RS16960 3559465..3559818 - 354 WP_181694942.1 DUF1428 family protein -
HVY60_RS16965 3559901..3560512 - 612 WP_174360590.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T165252 WP_002892050.1 NZ_CP057353:3556124-3556342 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T165252 NZ_CP073782:2213303-2213405 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14454.26 Da        Isoelectric Point: 5.5653

>AT165252 WP_115259201.1 NZ_CP057353:3555722-3556096 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165252 NZ_CP073782:c2213412-2213267 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References