Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2367869..2368638 Replicon chromosome
Accession NZ_CP057353
Organism Citrobacter freundii strain RHB29-C07

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HVY60_RS11095 Protein ID WP_181695612.1
Coordinates 2368156..2368638 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HVY60_RS11090 Protein ID WP_168246960.1
Coordinates 2367869..2368165 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY60_RS11075 2363369..2364556 + 1188 WP_146716827.1 outer membrane protein transport protein -
HVY60_RS11080 2364836..2365465 + 630 WP_117342784.1 winged helix-turn-helix transcriptional regulator -
HVY60_RS11085 2365774..2367756 + 1983 WP_137363302.1 MBL fold metallo-hydrolase -
HVY60_RS11090 2367869..2368165 + 297 WP_168246960.1 DUF1778 domain-containing protein Antitoxin
HVY60_RS11095 2368156..2368638 + 483 WP_181695612.1 GNAT family N-acetyltransferase Toxin
HVY60_RS11100 2368784..2369590 - 807 WP_181506995.1 SDR family oxidoreductase -
HVY60_RS11105 2369739..2370632 + 894 WP_153879559.1 LysR family transcriptional regulator -
HVY60_RS11110 2370667..2370948 - 282 Protein_2175 aldo/keto reductase -
HVY60_RS11115 2371402..2372451 + 1050 WP_181219782.1 NAD(P)-dependent alcohol dehydrogenase -
HVY60_RS11120 2372476..2372699 + 224 Protein_2177 hypothetical protein -
HVY60_RS11125 2372724..2373515 + 792 WP_181695613.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-146)

Antitoxin

Vibrio phage ICP1, Orf50

(17-91)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17798.38 Da        Isoelectric Point: 7.8926

>T165251 WP_181695612.1 NZ_CP057353:2368156-2368638 [Citrobacter freundii]
MEINVTAPALLTEGHDLQPFNCDNEVLNDWLRRRAIKNQYLNASRTFVICLESTQRVVGYYSIATGSVSHADLGRSLRQN
MPDPVPVVLLGRLAVDASTQGHSYGKWLLNDAVLRISNLADQVGIKAIMVHAIDGKARAFYEYFGFVQSPIAANTLFYKI

Download         Length: 483 bp

>T165251 NZ_CP073782:1827055-1827372 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACTCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11515.11 Da        Isoelectric Point: 5.8990

>AT165251 WP_168246960.1 NZ_CP057353:2367869-2368165 [Citrobacter freundii]
MEKLMQTSARKPTRDKQINIRATDEERAVIDYAASLVNKNRTDFIIEKAVHEAQNIILDQRVFVLDDARYQSFIEQLEAP
VQNVEGRQRLMDVKPEWK

Download         Length: 297 bp

>AT165251 NZ_CP073782:1827365-1827652 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References