Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798757..799411 Replicon chromosome
Accession NZ_CP057353
Organism Citrobacter freundii strain RHB29-C07

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HVY60_RS03985 Protein ID WP_096755799.1
Coordinates 799004..799411 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HVY60_RS03980 Protein ID WP_096755798.1
Coordinates 798757..799023 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY60_RS03955 793971..795404 - 1434 WP_115257538.1 6-phospho-beta-glucosidase BglA -
HVY60_RS03960 795525..796253 - 729 WP_115259901.1 MurR/RpiR family transcriptional regulator -
HVY60_RS03965 796306..796617 + 312 WP_096755795.1 N(4)-acetylcytidine aminohydrolase -
HVY60_RS03970 796781..797440 + 660 WP_096755796.1 hemolysin III family protein -
HVY60_RS03975 797520..798500 - 981 WP_115257540.1 tRNA-modifying protein YgfZ -
HVY60_RS03980 798757..799023 + 267 WP_096755798.1 FAD assembly factor SdhE Antitoxin
HVY60_RS03985 799004..799411 + 408 WP_096755799.1 protein YgfX Toxin
HVY60_RS03990 799457..799978 - 522 WP_096755800.1 flavodoxin FldB -
HVY60_RS03995 800091..800987 + 897 WP_181695294.1 site-specific tyrosine recombinase XerD -
HVY60_RS04000 801011..801724 + 714 WP_096755802.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY60_RS04005 801730..803463 + 1734 WP_181695295.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15935.93 Da        Isoelectric Point: 11.2851

>T165241 WP_096755799.1 NZ_CP057353:799004-799411 [Citrobacter freundii]
VVQWQSDLRVSWRAQWISLLIHGLVAVLILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMIKTGMMLRLRSSTGKRQHLWLAADSMDDAEWRDLRRLILQPSMQK

Download         Length: 408 bp

>T165241 NZ_CP073771:c3838044-3837634 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCGA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10570.10 Da        Isoelectric Point: 5.6311

>AT165241 WP_096755798.1 NZ_CP057353:798757-799023 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165241 NZ_CP073771:c3838291-3838025 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References