Detailed information of TA system TA165235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4786895..4787714
• Replicon: chromosome
• Accession: NZ_CP057330
• Organism: Klebsiella oxytoca strain RHB30-C02

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: HVY70_RS22545
• Protein ID: WP_004110819.1
• Coordinates: 4787457..4787714 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HVY70_RS22540
• Protein ID: WP_004099227.1
• Coordinates: 4786895..4787446 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVY70_RS22525	4782745..4784022	+	1278	WP_064344806.1	hypothetical protein	-
HVY70_RS22530	4784040..4785203	+	1164	WP_064344805.1	MFS transporter	-
HVY70_RS22535	4785249..4786877	-	1629	WP_064344804.1	SAM-dependent methyltransferase	-
HVY70_RS22540	4786895..4787446	-	552	WP_004099227.1	N-acetyltransferase	Antitoxin
HVY70_RS22545	4787457..4787714	-	258	WP_004110819.1	YjhX family toxin	Toxin
HVY70_RS22550	4788296..4789480	+	1185	WP_004099225.1	mannonate dehydratase	-
HVY70_RS22555	4789555..4791030	+	1476	WP_004110817.1	fructuronate reductase	-
HVY70_RS22560	4791166..4791942	+	777	WP_017146569.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T165235 WP_004110819.1 NZ_CP057330:c4787714-4787457 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T165235 NZ_CP073771:c300123-299821 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20246.21 Da
• Isoelectric Point: 6.7178

>AT165235 WP_004099227.1 NZ_CP057330:c4787446-4786895 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPRLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGITGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT165235 NZ_CP073771:c299814-299527 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2