165224

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 933357..934014 Replicon chromosome
Accession NZ_CP057330
Organism Klebsiella oxytoca strain RHB30-C02

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag HVY70_RS04520 Protein ID WP_004105559.1
Coordinates 933604..934014 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag HVY70_RS04515 Protein ID WP_004105561.1
Coordinates 933357..933623 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY70_RS04490 928537..929970 - 1434 WP_064343807.1 6-phospho-beta-glucosidase BglA -
HVY70_RS04495 930091..930819 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
HVY70_RS04500 930870..931181 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
HVY70_RS04505 931343..932002 + 660 WP_064344096.1 hemolysin III family protein -
HVY70_RS04510 932130..933113 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
HVY70_RS04515 933357..933623 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
HVY70_RS04520 933604..934014 + 411 WP_004105559.1 protein YgfX Toxin
HVY70_RS04525 934023..934544 - 522 WP_004105557.1 flavodoxin FldB -
HVY70_RS04530 934666..935562 + 897 WP_064343806.1 site-specific tyrosine recombinase XerD -
HVY70_RS04535 935585..936298 + 714 WP_064343805.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY70_RS04540 936304..938037 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T165224 WP_004105559.1 NZ_CP057330:933604-934014 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T165224 NZ_CP073768:2690576-2690683 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT165224 WP_004105561.1 NZ_CP057330:933357-933623 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165224 NZ_CP073768:c2690529-2690463 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References